The Fat Body and the Fat Brain can both cause the same type of symptoms, but fat loss and weight gain are often associated with the brain, according to research published online this week.
The findings shed new light on the role of the brain in fat loss, according, and show that brain inflammation may be a key to how the body handles the excess fat and insulin.
“The brain is a very, very important organ, and if you can’t manage the fat, then the brain can’t sustain you,” said Dr. James L. Scholl, a professor of psychiatry at the University of Southern California.
“We’re trying to understand how this can be triggered by brain inflammation.”
Brain inflammation is believed to play a key role in obesity.
It is believed that inflammation in the brain triggers a cascade of symptoms that are linked to a number of conditions, including insulin resistance, cardiovascular disease, depression and depression-related disorders.
The study, published in the Journal of Neuroscience, looked at the relationship between inflammation in neurons and weight loss.
The study involved the mice, which are genetically modified to lack certain proteins called insulin receptor substrate-1 (IRS-1), a key component of insulin signaling.
The researchers fed the mice an anabolic-androgenic diet and compared their weight loss to mice that ate an identical diet.
When they examined the mice’s brains, the scientists found inflammation was up to 30 times higher in the brains of the mice on the anabolic diet compared to the control group.
“When you lose weight, the inflammation increases.
And when you lose fat, the inflammatory increase decreases,” said Sholap Shah, a co-author and an associate professor of medicine at the USC School of Medicine.”
This means that inflammation may contribute to the development of obesity and weight regain.”
In a separate study, Shah and his colleagues found that inflammation was also a factor in the development and maintenance of diabetes, but the inflammation was linked to changes in gene expression that led to insulin resistance and insulin resistance-related metabolic diseases.
Shah and his team are currently investigating whether other molecules found in the fat body might also play a role in inflammation.
“In the future, we want to study the role that inflammation might play in obesity and diabetes,” Shah said.
In a study published earlier this year, Shah’s team found that when they measured the brain inflammation in mice, they found that the mice had a lower response to an insulin-stimulated release of the hormone insulin in response to food, suggesting that inflammation could contribute to obesity.
Sharma, who also has a special interest in obesity, said it is important to know the role inflammation plays in fat gain.
“If you are losing weight, you are less likely to develop metabolic diseases, so you have a better chance of avoiding the disease,” Sharma said.
“It’s important to understand that the inflammation we’re seeing in the gut and brain could be a trigger for the disease.”
This study was funded by the National Institutes of Health (grant P30AG02317).